The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

Long Noncoding RNAs in Pathological Cardiac Remodeling.

A novel long noncoding RNA Chaer acts as noncoding epigenetic regulator at the onset of cardiac hypertrophy and enables an improved understanding about the complex mechanisms in cardiovascular disease.

ATP-dependent chromatin remodeling shapes the long noncoding RNA landscape.

Long noncoding RNAs (lncRNAs) are pervasively transcribed across eukaryotic genomes, but functions of only a very small subset of them have been demonstrated. This has led to active debate about whether many of them have any biological functions. In addition, very few regulators of lncRNAs have been identified. We developed a novel genetic screen using reconstituted RNAi in Saccharomyces cerevi...

Quantum effects in ambient conditions.

Lnc-ing fibroblasts to cardiac fibrosis Therapies for cardiac injury typically focus on cardiomyocytes, the contractile cells of the heart. But cardiac fibroblasts can play a key role in the pathogenesis of heart failure by depositing extracellular matrix to compensate for reduced cardiac function. Micheletti et al. identified a long noncoding RNA (lncRNA), Wisper, that is enriched in cardiac f...

Decoding the Long Noncoding RNA During Cardiac Maturation

Study of Long Noncoding RNA FER1L4 and RB1, as Its Competing Endogenous RNA Network Target Gene, in Breast Cancer

Introduction: Breast cancer is the second most common cause of cancer-related death among females, which requires an exploration for markers to propose a more specific categorization of this cancer. Long noncoding RNAs (lncRNAs), the main subset of noncoding transcripts, are involved in tumorigenic processes. In this study, we investigated the expression of the fer-­1–­like family member 4 (FER...